Worthington is a city and county seat of Nobles County, Minnesota, United States. The population was 12,764 at the 2010 census.The city's site was first settled in the 1870s as Okabena Station on a line of the Chicago, St. Paul, Minneapolis and Omaha Railway, later the Chicago and North Western Railway where steam engines would take on water from adjacent Lake Okabena. More people entered along with one A.P. Miller of Toledo, Ohio, under a firm called the National Colony Organization. Miller named the new city after his wife's maiden name.